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Prof. Dr. Ali Avanoğlu
Vesicoureteral Reflux (VUR) • Basics

VUR Symptoms: How Is It Noticed?

Vesicoureteral reflux (VUR) does not cause a symptom of its own; in most children, the first and only clue is a febrile urinary tract infection. In babies, this infection shows up as fever with no obvious cause; in older children, it shows up as flank pain, chills, and voiding complaints. This page explains which signs should raise suspicion.

Who this is forFamilies whose child has had unexplained fever or a urinary tract infection and who suspect reflux
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ByProf. Dr. Ali AvanoğluUpdated
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In brief5 madde
  • Does VUR have a symptom of its own?: No, it does not.
  • Signs of VUR in babies: A baby cannot say 'it burns when I urinate'; the infection often shows up with fever alone.
  • Symptoms in older children: kidney or bladder?: In a child old enough to communicate, two pictures can be distinguished.
  • Before birth and before diagnosis: a finding, not a symptom: In some babies, the first sign of reflux is kidney enlargement seen on a prenatal ultrasound.
  • VUR symptoms in adults: Reflux that was not diagnosed in childhood may first come to light in adulthood through recurrent urinary tract infections, flank pain, high blood pressure, or…
01

Does VUR have a symptom of its own?

No, it does not. Urine flowing backward from the bladder toward the kidney does not cause pain, does not change urination, and produces no outward sign at all. Because of this, VUR is noticed not by its own 'symptoms' but by the consequences it causes or by incidental findings.

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  • There are three routes that lead to diagnosis: a febrile urinary tract infection, kidney enlargement (hydronephrosis) seen on a prenatal or postnatal ultrasound, and screening carried out because of a family history of reflux. Of these, infection is the most common; when children with febrile urinary tract infections are investigated, reflux is found in about 25–40% of them.
  • So the main thing families need to learn is not what reflux looks like, but what a urinary tract infection looks like in a child. This picture differs considerably by age.
02

Signs of VUR in babies

A baby cannot say 'it burns when I urinate'; the infection often shows up with fever alone. Whenever there is a temperature of 38°C or higher with no obvious source — such as a cold, cough, ear pain, or rash — a urinary tract infection should always be considered. The younger the child, the fainter and more deceptive the signs.

  • Fever of 38°C or higher with no obvious source
  • Poor feeding, drowsiness, unusual fussiness
  • Vomiting, diarrhea, poor weight gain, or weight loss
  • Prolonged or recurring jaundice in a newborn
  • Sharp-smelling, cloudy urine on the diaper
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  • In newborns and young infants, there may not even be fever; instead, there may be poor feeding, drowsiness, unusual fussiness, vomiting, diarrhea, poor weight gain, or prolonged jaundice. A sharp smell or cloudy color of the urine on the diaper may alert the family, but odor alone does not establish a diagnosis.
  • In this picture, it is very important that the sample for urinalysis and urine culture is collected using the correct method; urine cultures collected with a bag often give false results.
03

Symptoms in older children: kidney or bladder?

In a child old enough to communicate, two pictures can be distinguished. Fever, chills, flank or back pain, vomiting, and malaise suggest a kidney infection (pyelonephritis); this is the picture that matters for reflux. Burning on urination alone, frequent small-volume voiding, urgency, and lower abdominal pain, on the other hand, are usually a bladder infection (cystitis) and are not on their own a sign of reflux.

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  • Attention should also be paid to voiding habits that often occur together with reflux: holding behaviors such as withholding urine for long periods, squatting, or crossing the legs, daytime wetting, constipation, or stool soiling. These are all part of bladder-bowel dysfunction (BBD); they make both infection and the persistence of reflux more likely.
  • There is one more distinction here: a child wetting themselves is not a symptom of reflux. But when daytime wetting occurs together with recurrent infection, bladder function and reflux are evaluated together.
04

Before birth and before diagnosis: a finding, not a symptom

In some babies, the first sign of reflux is kidney enlargement seen on a prenatal ultrasound. This is not a symptom but an incidental finding; the baby appears completely healthy at birth.

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  • About 10–20% of babies found to have antenatal kidney enlargement are found to have reflux on postnatal evaluation; this likelihood rises if the enlargement is marked, if the ureter is also dilated, or if there is a duplex collecting system. In these babies, staying alert for fever in the first months is the most important form of 'symptom watch' until the diagnostic process is complete.
  • There are also cases of reflux noticed incidentally years later: mild enlargement seen on an ultrasound done for another reason, or during a sibling's screening. Most of these children have never had an infection, and the approach taken is gentler.
05

VUR symptoms in adults

Reflux that was not diagnosed in childhood may first come to light in adulthood through recurrent urinary tract infections, flank pain, high blood pressure, or protein found on a urinalysis. Increased infection frequency during pregnancy is also one of the ways reflux is noticed in adults.

  • Most reflux detected in adulthood is a holdover from childhood, and whether it has left scarring in the kidney is more decisive than the grade of reflux itself. For this reason, evaluation calls for blood pressure measurement, a check for protein in the urine, and kidney imaging together.
06

When should you see a doctor?

Whether or not there is a diagnosis of reflux, suspected febrile urinary tract infection in a child calls for same-day evaluation; early treatment reduces the likelihood of kidney scarring. Rather than giving a fever reducer and waiting, a urine sample should be collected using the correct method before antibiotics are started.

  • Fever of unclear source in a baby, especially if younger than 3 months
  • Fever together with flank pain, chills, or vomiting
  • New fever in a child who has previously had a urinary tract infection
  • Any fever in a child already diagnosed with reflux or kidney enlargement
  • Frequent recurring voiding complaints together with constipation or daytime wetting
  • From the diagnostic stage onward, our physicians give the family a written 'what to do if there is fever' plan; this way, antibiotics are not started without a culture when a fever begins on a weekend or at night. We recommend seeking care without delay in the following situations.
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Frequently asked questions
My child had a urinary tract infection without fever; could it be reflux?
It's possible, but less likely. The picture that really calls for a reflux work-up is a febrile infection — one involving the kidney. If afebrile infections keep recurring, voiding habits and constipation are reviewed first; ultrasound and, if needed, further testing are planned based on the physician's assessment.
Is bad-smelling urine a sign of reflux?
No. Odor varies with fluid intake, diet, and how long the diaper has been on; on its own it does not indicate infection or reflux. If the odor is accompanied by fever, fussiness, or voiding complaints, it is worth getting a urinalysis.
Should reflux be suspected in a child who wets the bed at night?
In a child who only wets at night, is dry during the day, and has never had an infection, a reflux work-up is not needed. If daytime wetting, urgency, and recurrent infection occur together, bladder function and, if necessary, reflux are evaluated together.
In a child with flank pain, should reflux or a kidney stone be suspected?
Both can be considered; flank pain together with fever primarily suggests a kidney infection. Urinalysis, culture, and ultrasound usually make this distinction. Same-day evaluation is needed when the pain is severe or is accompanied by vomiting.
Related pagesFull index →
Kidney health and infectionPyelonephritis in Children (Febrile UTI): Symptoms and When It's an EmergencyPyelonephritis is a febrile urinary tract infection (febrile UTI) in which bacteria travel up from the bladder and reach the kidney tissue. In children, it is the most common way kidney reflux first comes to light, and it is the main cause of scarring — which is why rapid diagnosis and timely treatment matter so much. This page covers symptoms by age, the warning signs for urgent care, how treatment is planned, and what is investigated afterward.Diagnosis and evaluationVUR Evaluation After a Febrile Urinary Tract Infection: Who Needs a VCUG?Roughly 25–40% of children who have a febrile urinary tract infection (UTI) are found to have vesicoureteral reflux (VUR). But that doesn't mean every child needs an immediate VCUG. This page explains which test is done for whom, in what order, and when, after an infection.Diagnosis and evaluationUrinalysis and Urine Culture in Children: How to Collect the Right SampleEvaluation of vesicoureteral reflux (VUR) most often begins with a urine culture. A sample collected the wrong way can lead to unnecessary treatment or can mask a real infection. This page explains how to collect the right sample in infants and children, and what the results mean.Diagnosis and evaluationKidney Enlargement Before Birth (Antenatal Hydronephrosis) and VURHearing the words ‘kidney enlargement’ or ‘kidney dilation’ on a pregnancy ultrasound worries families; yet most antenatal hydronephrosis is transient and resolves on its own after birth. Even so, roughly 10–20% of these infants are found to have vesicoureteral reflux (VUR). This page explains what the enlargement means and which tests are done, and when, after birth.
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